| Title |
Uptake and intracellular traffic of siRNA dendriplexes in glioblastoma cells and macrophages
|
|---|---|
| Published in |
International Journal of Nanomedicine, November 2011
|
| DOI | 10.2147/ijn.s25235 |
| Pubmed ID | |
| Authors |
Ana Paula Perez, Maria Luz Cosaka, Eder Lilia Romero, Maria Jose Morilla |
| Abstract |
Gene silencing using small interfering RNA (siRNA) is a promising new therapeutic approach for glioblastoma. The endocytic uptake and delivery of siRNA to intracellular compartments could be enhanced by complexation with polyamidoamine dendrimers. In the present work, the uptake mechanisms and intracellular traffic of siRNA/generation 7 dendrimer complexes (siRNA dendriplexes) were screened in T98G glioblastoma and J774 macrophages. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 45 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 28% |
| Student > Bachelor | 6 | 13% |
| Researcher | 5 | 11% |
| Student > Master | 4 | 9% |
| Student > Doctoral Student | 3 | 6% |
| Other | 5 | 11% |
| Unknown | 11 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 28% |
| Medicine and Dentistry | 6 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Chemistry | 4 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 13 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2021.
All research outputs
#7,960,693
of 25,374,917 outputs
Outputs from International Journal of Nanomedicine
#940
of 4,122 outputs
Outputs of similar age
#47,916
of 153,816 outputs
Outputs of similar age from International Journal of Nanomedicine
#17
of 59 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,122 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 153,816 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.