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Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury

Overview of attention for article published in International Journal of Nanomedicine, July 2012
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Title
Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury
Published in
International Journal of Nanomedicine, July 2012
DOI 10.2147/ijn.s32824
Pubmed ID
Authors

Václav Vaněček, Vitalii Zablotskii, Serhiy Forostyak, Jiří Růřička, Vít Herynek, Michal Babič, Pavla Jendelová, Šárka Kubinová, Alexandr Dejneka, Eva Syková

Abstract

The transplantation of mesenchymal stem cells (MSC) is currently under study as a therapeutic approach for spinal cord injury, and the number of transplanted cells that reach the lesioned tissue is one of the critical parameters. In this study, intrathecally transplanted cells labeled with superparamagnetic iron oxide nanoparticles were guided by a magnetic field and successfully targeted near the lesion site in the rat spinal cord. Magnetic resonance imaging and histological analysis revealed significant differences in cell numbers and cell distribution near the lesion site under the magnet in comparison to control groups. The cell distribution correlated well with the calculated distribution of magnetic forces exerted on the transplanted cells in the subarachnoid space and lesion site. The kinetics of the cells' accumulation near the lesion site is described within the framework of a mathematical model that reveals those parameters critical for cell targeting and suggests ways to enhance the efficiency of magnetic cell delivery. In particular, we show that the targeting efficiency can be increased by using magnets that produce spatially modulated stray fields. Such magnetic systems with tunable geometric parameters may provide the additional level of control needed to enhance the efficiency of stem cell delivery in spinal cord injury.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
United Kingdom 2 3%
China 1 1%
Unknown 77 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 31%
Researcher 11 14%
Student > Bachelor 10 13%
Student > Master 9 11%
Student > Postgraduate 4 5%
Other 12 15%
Unknown 9 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 18%
Medicine and Dentistry 13 16%
Engineering 11 14%
Neuroscience 6 8%
Physics and Astronomy 5 6%
Other 18 23%
Unknown 13 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2012.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from International Journal of Nanomedicine
#3,127
of 4,123 outputs
Outputs of similar age
#138,232
of 176,748 outputs
Outputs of similar age from International Journal of Nanomedicine
#74
of 98 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,748 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.