Title |
Antitumor activity of folate-targeted, paclitaxel-loaded polymeric micelles on a human esophageal EC9706 cancer cell line
|
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Published in |
International Journal of Nanomedicine, July 2012
|
DOI | 10.2147/ijn.s32620 |
Pubmed ID | |
Authors |
Wenbin Wu, Yonghui Zheng, Rui Wang, Weili Huang, Lei Liu, Xiuli Hu, Shi Liu, Jun Yue, Ti Tong, Xiabin Jing |
Abstract |
Esophageal cancer is recognized as one of the most refractory pernicious diseases. In addition, it is an aggressive malignancy with a propensity for local progression and distant dissemination. Because of the poor long-term prognosis for patients with esophageal cancer, increasing attention has focused on the integration of targeted agents into current therapeutics. Nevertheless, there have been few studies reported concerning the therapeutic efficacy of paclitaxel-conjugated polymeric micelles in human esophageal cancer in vivo. Therefore, the aim of this research was to investigate the tumor inhibition effect of composite micelles containing folic acid and paclitaxel on the human esophageal EC9706 cancer cell line. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 30% |
Student > Doctoral Student | 3 | 10% |
Student > Master | 3 | 10% |
Researcher | 3 | 10% |
Student > Postgraduate | 2 | 7% |
Other | 2 | 7% |
Unknown | 8 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 20% |
Agricultural and Biological Sciences | 4 | 13% |
Chemistry | 4 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
Physics and Astronomy | 2 | 7% |
Other | 4 | 13% |
Unknown | 7 | 23% |