| Title |
Towards development of novel immunization strategies against leishmaniasis using PLGA nanoparticles loaded with kinetoplastid membrane protein-11
|
|---|---|
| Published in |
International Journal of Nanomedicine, April 2012
|
| DOI | 10.2147/ijn.s30093 |
| Pubmed ID | |
| Authors |
Diego M Santos, Marcia W Carneiro, Tatiana R de Moura, Kiyoshi Fukutani, Jorge Clarencio, Manuel Soto, Socorro Espuelas, Claudia Brodskyn, Aldina Barral, Manoel Barral-Netto, Camila I de Oliveira |
| Abstract |
Vaccine development has been a priority in the fight against leishmaniases, which are vector-borne diseases caused by Leishmania protozoa. Among the different immunization strategies employed to date is inoculation of plasmid DNA coding for parasite antigens, which has a demonstrated ability to induce humoral and cellular immune responses. In this sense, inoculation of plasmid DNA encoding Leishmania kinetoplasmid membrane protein-11 (KMP-11) was able to confer protection against visceral leishmaniasis. However, recently the use of antigen delivery systems such as poly(lactic-co-glycolic acid) (PLGA) nanoparticles has also proven effective for eliciting protective immune responses. |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 82 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 19% |
| Student > Ph. D. Student | 13 | 15% |
| Researcher | 11 | 13% |
| Student > Bachelor | 9 | 11% |
| Student > Doctoral Student | 6 | 7% |
| Other | 13 | 15% |
| Unknown | 16 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 29% |
| Biochemistry, Genetics and Molecular Biology | 14 | 17% |
| Veterinary Science and Veterinary Medicine | 6 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Immunology and Microbiology | 4 | 5% |
| Other | 12 | 14% |
| Unknown | 19 | 23% |