| Title |
Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice
|
|---|---|
| Published in |
International Journal of Nanomedicine, June 2012
|
| DOI | 10.2147/ijn.s29145 |
| Pubmed ID | |
| Authors |
Hardeep S Oberoi, Natalia V Nukolova, Frederic C Laquer, Larisa Y Poluektova, Jiangeng Huang, Yazen Alnouti, Masanao Yokohira, Lora L Arnold, Alexander V Kabanov, Samuel M Cohen, Tatiana K Bronich |
| Abstract |
Polymer micelles with cross-linked ionic cores are shown here to improve the therapeutic performance of the platinum-containing anticancer compound cisplatin. Biodistribution, antitumor efficacy, and toxicity of cisplatin-loaded core cross-linked micelles of poly(ethylene glycol)-b-poly(methacrylic acid) were evaluated in a mouse ovarian cancer xenograft model. Cisplatin-loaded micelles demonstrated prolonged blood circulation, increased tumor accumulation, and reduced renal exposure. Improved antitumor response relative to free drug was seen in a mouse model. Toxicity studies with cisplatin-loaded micelles indicate a significantly improved safety profile and lack of renal abnormalities typical of free cisplatin treatment. Overall, the study supports the fundamental possibility of improving the potential of platinum therapy using polymer micelle-based drug delivery. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 43 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 30% |
| Student > Bachelor | 6 | 14% |
| Researcher | 5 | 11% |
| Other | 4 | 9% |
| Student > Master | 4 | 9% |
| Other | 5 | 11% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 23% |
| Medicine and Dentistry | 7 | 16% |
| Chemistry | 5 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Materials Science | 3 | 7% |
| Other | 7 | 16% |
| Unknown | 9 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2012.
All research outputs
#20,823,121
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#3,113
of 4,077 outputs
Outputs of similar age
#140,316
of 179,466 outputs
Outputs of similar age from International Journal of Nanomedicine
#71
of 82 outputs
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