Title |
Correlation between radioactivity and chemotherapeutics of the 111In-VNB-liposome in pharmacokinetics and biodistribution in rats
|
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Published in |
International Journal of Nanomedicine, February 2012
|
DOI | 10.2147/ijn.s28279 |
Pubmed ID | |
Authors |
Wen-Chuan Lee, Chih-Hsien Chang, Chih-Min Huang, Yu-Tse Wu, Liang-Cheng Chen, Chung-Li Ho, Tsui-Jung Chang, Te-Wei Lee, Tung-Hu Tsai |
Abstract |
The combination of a radioisotope with a chemotherapeutic agent in a liposomal carrier (ie, Indium-111-labeled polyethylene glycol pegylated liposomal vinorelbine, [(111)In-VNB-liposome]) has been reported to show better therapeutic efficiency in tumor growth suppression. Nevertheless, the challenge remains as to whether this therapeutic effect is attributable to the combination of a radioisotope with chemotherapeutics. The goal of this study was to investigate the pharmacokinetics, biodistribution, and correlation of Indium-111 radioactivity and vinorelbine concentration in the (111)In-VNB-liposome. |
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