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Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation

Overview of attention for article published in International Journal of Nanomedicine, March 2012
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
2 tweeters

Citations

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37 Dimensions

Readers on

mendeley
37 Mendeley
Title
Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
Published in
International Journal of Nanomedicine, March 2012
DOI 10.2147/ijn.s27159
Pubmed ID
Authors

Ji Won Park, Jang, Cha, Jung, JE Lee, Jung, Ju Ock Kim, SY Kim, Lee, H Park

Abstract

The anti-inflammatory action of silver nanoparticles (NPs) has been reported in a murine model of asthma in a previous study. But more specific mechanisms of silver NPs in an attenuation of allergic airway inflammation have not yet been established. Vascular and mucous changes are believed to contribute largely in pathophysiology in asthma. Among various factors related to vascular changes, vascular endothelial growth factor (VEGF) plays a pivotal role in vascular changes in asthma. Mucin proteins MUC5AC and MUC5B have been implicated as markers of goblet cell metaplasia in lung pathologies. The aim of this study was to investigate the effects of silver NPs on VEGF signaling pathways and mucus hypersecretion. Ovalbumin (OVA)-inhaled female BALBc mice were used to evaluate the role of silver NPs and the related molecular mechanisms in allergic airway disease. In this study, with an OVA-induced murine model of allergic airway disease, it was found that the increased levels of hypoxia-inducible factor (HIF)-1α, VEGF, phosphatidylinositol-3 kinase (PI3K) and phosphorylated-Akt levels, and mucous glycoprotein expression (Muc5ac) in lung tissues were substantially decreased by the administration of silver NPs. In summary, silver NPs substantially suppressed mucus hypersecretion and PI3K/HIF-1α/VEGF signaling pathway in an allergic airway inflammation.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 3%
United States 1 3%
Singapore 1 3%
Unknown 34 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 38%
Researcher 7 19%
Professor > Associate Professor 4 11%
Student > Doctoral Student 3 8%
Student > Master 2 5%
Other 3 8%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 35%
Medicine and Dentistry 6 16%
Engineering 3 8%
Biochemistry, Genetics and Molecular Biology 2 5%
Chemistry 2 5%
Other 3 8%
Unknown 8 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2012.
All research outputs
#9,556,301
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#1,797
of 2,456 outputs
Outputs of similar age
#81,634
of 120,428 outputs
Outputs of similar age from International Journal of Nanomedicine
#40
of 78 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,428 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.