Title |
Current progress in the development of a prophylactic vaccine for HIV-1
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Published in |
Drug Design, Development and Therapy, December 2010
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DOI | 10.2147/dddt.s6959 |
Pubmed ID | |
Authors |
Lena J Gamble, Qiana L Matthews |
Abstract |
Since its discovery and characterization in the early 1980s as a virus that attacks the immune system, there has been some success for the treatment of human immunodeficiency virus-1 (HIV-1) infection. However, due to the overwhelming public health impact of this virus, a vaccine is needed urgently. Despite the tireless efforts of scientist and clinicians, there is still no safe and effective vaccine that provides sterilizing immunity. A vaccine that provides sterilizing immunity against HIV infection remains elusive in part due to the following reasons: 1) degree of diversity of the virus, 2) ability of the virus to evade the hosts' immunity, and 3) lack of appropriate animal models in which to test vaccine candidates. There have been several attempts to stimulate the immune system to provide protection against HIV-infection. Here, we will discuss attempts that have been made to induce sterilizing immunity, including traditional vaccination attempts, induction of broadly neutralizing antibody production, DNA vaccines, and use of viral vectors. Some of these attempts show promise pending continued research efforts. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 5% |
Germany | 1 | 2% |
Italy | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 51 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 23% |
Researcher | 11 | 19% |
Student > Master | 10 | 18% |
Student > Bachelor | 8 | 14% |
Student > Postgraduate | 4 | 7% |
Other | 4 | 7% |
Unknown | 7 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 47% |
Medicine and Dentistry | 11 | 19% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Nursing and Health Professions | 2 | 4% |
Engineering | 2 | 4% |
Other | 2 | 4% |
Unknown | 7 | 12% |