| Title |
Inherited variation in pattern recognition receptors and cancer: dangerous liaisons?
|
|---|---|
| Published in |
Cancer Management and Research, February 2012
|
| DOI | 10.2147/cmar.s28688 |
| Pubmed ID | |
| Authors |
Anton G Kutikhin, Arseniy E Yuzhalin |
| Abstract |
The group of pattern recognition receptors includes families of Toll-like receptors, NOD-like receptors, C-type lectin receptors, and RIG-I-like receptors. They are key sensors for a number of infectious agents, some of which are carcinogenic, and they launch an immune response against them. Inherited structural variation in genes encoding these receptors and proteins of their signaling pathways may affect their function, modulating cancer risk and features of cancer progression. Relevant malignancies, valuable gene polymorphisms, prime questions about future directions, and answers to these questions are analyzed in this review. It is possible to suggest that polymorphisms of genes encoding pattern recognition receptors and proteins of their signaling pathways may be associated with almost all cancer types, particularly with those in which carcinogenic infectious agents are responsible for the substantial share of cases (namely gastric cancer, colorectal cancer, liver cancer, cervical cancer, and nasopharyngeal carcinoma). The concept of selection of polymorphisms for further oncogenomic investigation, based on a combination of results from basic and epidemiological studies, is proposed. |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 24% |
| Student > Ph. D. Student | 6 | 21% |
| Student > Bachelor | 5 | 17% |
| Student > Master | 2 | 7% |
| Other | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 5 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 31% |
| Biochemistry, Genetics and Molecular Biology | 4 | 14% |
| Chemistry | 3 | 10% |
| Immunology and Microbiology | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 7 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2020.
All research outputs
#7,414,686
of 22,671,366 outputs
Outputs from Cancer Management and Research
#333
of 1,988 outputs
Outputs of similar age
#71,785
of 247,275 outputs
Outputs of similar age from Cancer Management and Research
#3
of 8 outputs
Altmetric has tracked 22,671,366 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,988 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 80% of its peers.
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