| Title |
Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study
|
|---|---|
| Published in |
Clinical, Cosmetic and Investigational Dermatology, February 2012
|
| DOI | 10.2147/ccid.s29537 |
| Pubmed ID | |
| Authors |
Enzo Emanuele, Marco Bertona, Karmela Altabas, Velimir Altabas, Giuseppe Alessandrini |
| Abstract |
Acne vulgaris is a skin disorder of the sebaceous follicles, involving hyperkeratinization and perifollicular inflammation. Aberrant extracellular matrix remodeling due to matrix metalloproteinases (MMPs) has been associated with the presence of acne conditions. Given the complex pathophysiology of acne, novel topical therapies should include combination products that target multiple pathogenetic mechanisms. In this pilot study we investigated the changes in gene expression of extracellular MMPs, the tissue inhibitors of metalloproteinases, and proinflammatory molecules after 45 days of topical application of a combination product containing nicotinamide, retinol, and 7-dehydrocholesterol in 16 patients with inflammatory acne on their back. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Thailand | 2 | 11% |
| Japan | 1 | 5% |
| United Kingdom | 1 | 5% |
| Mexico | 1 | 5% |
| Unknown | 14 | 74% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 89% |
| Scientists | 1 | 5% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 5% |
| Unknown | 18 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 26% |
| Student > Master | 4 | 21% |
| Student > Postgraduate | 2 | 11% |
| Researcher | 2 | 11% |
| Student > Bachelor | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 32% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
| Agricultural and Biological Sciences | 2 | 11% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Chemical Engineering | 1 | 5% |
| Other | 2 | 11% |
| Unknown | 4 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2023.
All research outputs
#1,296,294
of 25,584,565 outputs
Outputs from Clinical, Cosmetic and Investigational Dermatology
#111
of 900 outputs
Outputs of similar age
#8,339
of 254,308 outputs
Outputs of similar age from Clinical, Cosmetic and Investigational Dermatology
#1
of 2 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 900 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.5. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 254,308 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them