| Title |
Natural killer cells: role in local tumor growth and metastasis
|
|---|---|
| Published in |
Biologics: Targets & Therapy, April 2012
|
| DOI | 10.2147/btt.s23976 |
| Pubmed ID | |
| Authors |
Inge Langers, Virginie M Renoux, Marc Thiry, Philippe Delvenne, Nathalie Jacobs |
| Abstract |
Historically, the name of natural killer (NK) cells came from their natural ability to kill tumor cells in vitro. From the 1970s to date, accumulating data highlighted the importance of NK cells in host immune response against cancer and in therapy-induced antitumor response. The recognition and the lysis of tumor cells by NK cells are regulated by a complex balance of inhibitory and activating signals. This review summarizes NK cell mechanisms to kill cancer cells, their role in host immune responses against tumor growth or metastasis, and their implications in antitumor immunotherapies via cytokines, antibodies, or in combination with other therapies. The regulatory role of NK cells in autoimmunity is also discussed. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 1% |
| Denmark | 1 | <1% |
| Germany | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 151 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 20% |
| Student > Bachelor | 29 | 19% |
| Student > Master | 21 | 13% |
| Researcher | 20 | 13% |
| Student > Doctoral Student | 9 | 6% |
| Other | 14 | 9% |
| Unknown | 32 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 25% |
| Biochemistry, Genetics and Molecular Biology | 31 | 20% |
| Medicine and Dentistry | 20 | 13% |
| Immunology and Microbiology | 16 | 10% |
| Engineering | 3 | 2% |
| Other | 11 | 7% |
| Unknown | 36 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2023.
All research outputs
#4,287,990
of 25,806,080 outputs
Outputs from Biologics: Targets & Therapy
#52
of 286 outputs
Outputs of similar age
#26,757
of 173,865 outputs
Outputs of similar age from Biologics: Targets & Therapy
#1
of 7 outputs
Altmetric has tracked 25,806,080 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 286 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,865 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them