Title |
Volumetric brain abnormalities in polysubstance use disorder patients
|
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Published in |
Neuropsychiatric Disease and Treatment, June 2016
|
DOI | 10.2147/ndt.s107733 |
Pubmed ID | |
Authors |
Cemal Onur Noyan, Samet Kose, Serdar Nurmedov, Baris Metin, Aslı Enez Darcin, Nesrin Dilbaz |
Abstract |
Polysubstance users represent the largest group of patients seeking treatment at addiction and rehabilitation clinics in Turkey. There is little knowledge about the structural brain abnormalities seen in polysubstance users. This study was conducted to examine the structural brain differences between polysubstance use disorder patients and healthy control subjects using voxel-based morphometry. Forty-six male polysubstance use disorder patients in the early abstinence period and 30 healthy male controls underwent structural magnetic resonance imaging scans. Voxel-based morphometry analysis was performed to examine gray matter (GM) abnormality differences. Polysubstance use disorder patients displayed significantly smaller GM volume in the thalamus, temporal pole, superior frontal gyrus, cerebellum, gyrus rectus, occipital lobe, anterior cingulate cortex, superior temporal gyrus, and postcentral gyrus. A widespread and smaller GM volume has been found at different regions of the frontal, temporal, occipital, and parietal lobes, cerebellum, and anterior cingulate cortex in polysubstance users. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Turkey | 3 | 43% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 43% |
Members of the public | 2 | 29% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 4 | 14% |
Researcher | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Student > Bachelor | 2 | 7% |
Other | 7 | 24% |
Unknown | 8 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 8 | 28% |
Medicine and Dentistry | 5 | 17% |
Neuroscience | 3 | 10% |
Social Sciences | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 0 | 0% |
Unknown | 11 | 38% |