Title |
Lenalidomide for the treatment of relapsed and refractory multiple myeloma
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Published in |
Cancer Management and Research, August 2012
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DOI | 10.2147/cmar.s27087 |
Pubmed ID | |
Authors |
Niels WCJ van de Donk, Güllü Görgün, Richard WJ Groen, Jana Jakubikova, Constantine S Mitsiades, Teru Hideshima, Jacob Laubach, Inger S Nijhof, Reinier A Raymakers, Henk M Lokhorst, Paul G Richardson, Kenneth C Anderson |
Abstract |
Lenalidomide is an amino-substituted derivative of thalidomide with direct antiproliferative and cytotoxic effects on the myeloma tumor cell, as well as antiangiogenic activity and immunomodulatory effects. Together with the introduction of bortezomib and thalidomide, lenalidomide has significantly improved the survival of patients with relapsed and refractory myeloma. The most common adverse events associated with lenalidomide include fatigue, skin rash, thrombocytopenia, and neutropenia. In addition, when lenalidomide is combined with dexamethasone or other conventional cytotoxic agents, there is an increase in the incidence of venous thromboembolic events. There is now evidence that continued treatment with lenalidomide has a significant impact on survival by improving the depth and duration of response. This highlights the value of adverse event management and appropriate dose adjustments to prevent toxicity, and of allowing continued treatment until disease progression. In this review, we will discuss the different lenalidomide-based treatment regimens for patients with relapsed/refractory myeloma. This is accompanied by recommendations of how to manage and prevent adverse events associated with lenalidomide-based therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 60% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 40% |
Scientists | 2 | 40% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Belgium | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 106 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 15% |
Other | 13 | 12% |
Student > Ph. D. Student | 13 | 12% |
Student > Master | 12 | 11% |
Student > Bachelor | 10 | 9% |
Other | 27 | 25% |
Unknown | 18 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 40% |
Agricultural and Biological Sciences | 12 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 8% |
Nursing and Health Professions | 5 | 5% |
Biochemistry, Genetics and Molecular Biology | 5 | 5% |
Other | 15 | 14% |
Unknown | 20 | 18% |