| Title |
Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, June 2016
|
| DOI | 10.2147/ndt.s110978 |
| Pubmed ID | |
| Authors |
Alireza Rahimi, Mohammad Ahmadpanah, Farshid Shamsaei, Fatemeh Cheraghi, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand |
| Abstract |
Sleep disturbances are a common co-occurring disturbance in patients with major depressive disorders (MDDs) and accordingly deserve particular attention. Using a randomized design, we investigated the effects of three different adjuvant interventions on sleep and depression among patients with MDD: a sleep hygiene program (SHP), lorazepam (LOR), and their combination (SHP-LOR). A total of 120 outpatients with diagnosed MDD (mean age: 48.25 years; 56.7% females) and treated with a standard SSRI (citalopram at 20-40 mg at therapeutic level) were randomly assigned to one of the following three conditions: SHP (n=40), LOR (1 mg/d; n=40), SHP-LOR (1 mg/d; n=40). At the beginning and at the end of the study 8 weeks later, patients completed two questionnaires, the Pittsburgh Sleep Quality Index to assess sleep and the Beck Depression Inventory to assess symptoms of depression. Sleep disturbances decreased over time and in all groups. No group differences or interactions were observed. Symptoms of depression decreased over time and in all three groups. Reduction in symptoms of depression was greatest in the SHP-LOR group and lowest in the LOR group. The pattern of results suggests that all three adjuvant treatments improved symptoms of sleep disturbances and depression, with greater benefits for the SHP-LOR for symptoms of depression, but not for sleep. Nevertheless, risks and benefits of benzodiazepine prescriptions should be taken into account. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 105 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 27 | 26% |
| Student > Master | 13 | 12% |
| Student > Ph. D. Student | 8 | 8% |
| Student > Doctoral Student | 4 | 4% |
| Other | 4 | 4% |
| Other | 13 | 12% |
| Unknown | 36 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 19% |
| Psychology | 19 | 18% |
| Nursing and Health Professions | 11 | 10% |
| Neuroscience | 4 | 4% |
| Unspecified | 3 | 3% |
| Other | 9 | 9% |
| Unknown | 39 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2016.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,902
of 3,132 outputs
Outputs of similar age
#225,301
of 353,659 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#66
of 94 outputs
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