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Effects of the protein corona on liposome–liposome and liposome–cell interactions

Overview of attention for article published in International Journal of Nanomedicine, July 2016
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Mentioned by

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2 tweeters

Citations

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46 Dimensions

Readers on

mendeley
77 Mendeley
Title
<div>Effects of the protein corona on liposome&ndash;liposome and liposome&ndash;cell interactions</div>
Published in
International Journal of Nanomedicine, July 2016
DOI 10.2147/ijn.s109059
Pubmed ID
Authors

Ennio Tasciotti, Roberto Molinaro, Francesca Taraballi, Naama Toledano Furman, Michael Sherman, Alessandro Parodi, Francesco Salvatore, Claudia Corbo

Abstract

A thorough understanding of interactions occurring at the interface between nanocarriers and biological systems is crucial to predict and interpret their biodistribution, targeting, and efficacy, and thus design more effective drug delivery systems. Upon intravenous injection, nanoparticles are coated by a protein corona (PC). This confers a new biological identity on the particles that largely determines their biological fate. Liposomes have great pharmaceutical versatility, so, as proof of concept, their PC has recently been implicated in the mechanism and efficiency of their internalization into the cell. In an attempt to better understand the interactions between nanocarriers and biological systems, we analyzed the plasma proteins adsorbed on the surface of multicomponent liposomes. Specifically, we analyzed the physical properties and ultrastructure of liposome/PC complexes and the aggregation process that occurs when liposomes are dispersed in plasma. The results of combined confocal microscopy and flow cytometry experiments demonstrated that the PC favors liposome internalization by both macrophages and tumor cells. This work provides insights into the effects of the PC on liposomes' physical properties and, consequently, liposome-liposome and liposome-cell interactions.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
South Africa 1 1%
Unknown 75 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 22%
Student > Master 13 17%
Student > Bachelor 12 16%
Researcher 8 10%
Student > Postgraduate 6 8%
Other 10 13%
Unknown 11 14%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 16 21%
Chemistry 13 17%
Biochemistry, Genetics and Molecular Biology 12 16%
Medicine and Dentistry 5 6%
Agricultural and Biological Sciences 5 6%
Other 12 16%
Unknown 14 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2016.
All research outputs
#4,196,949
of 7,992,937 outputs
Outputs from International Journal of Nanomedicine
#992
of 1,780 outputs
Outputs of similar age
#141,571
of 260,267 outputs
Outputs of similar age from International Journal of Nanomedicine
#100
of 129 outputs
Altmetric has tracked 7,992,937 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,780 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,267 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.