Title |
Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females
|
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Published in |
Journal of Pain Research, August 2012
|
DOI | 10.2147/jpr.s33559 |
Pubmed ID | |
Authors |
Espen Bjørkedal, Magne Arve Flaten |
Abstract |
Chronic pain is believed to be related to a dysfunction of descending pain modulatory mechanisms. Functioning of descending pain modulation can be assessed by various methods, including conditioned pain modulation (CPM). CPM refers to the inhibition of one source of pain by a second noxious stimulus, termed the conditioning stimulus. This procedure can activate an endogenous pain inhibitory mechanism that inhibits early nociceptive processing. Chronic pain and anxiety disorders are more prevalent among females and it has been hypothesized that females react with more negative emotions towards unpleasant stimuli and this might be part of the explanation of greater pain sensitivity in females. The present study investigated whether expectations modulate the effect of conditioning stimulation on pain, subjective stress, and heart rate. In addition, we investigated whether the modulation of CPM by expectations differed between males and females. |
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