Title |
Challenge models to assess new therapies in chronic obstructive pulmonary disease
|
---|---|
Published in |
International Journal of Chronic Obstructive Pulmonary Disease, September 2012
|
DOI | 10.2147/copd.s30664 |
Pubmed ID | |
Authors |
René van der Merwe, Nestor A Molfino |
Abstract |
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Current therapies confer partial benefits either by incompletely improving airflow limitation or by reducing acute exacerbations, hence new therapies are desirable. In the absence of robust early predictors of clinical efficacy, the potential success of novel therapeutic agents in COPD will not entirely be known until the drugs enter relatively large and costly clinical trials. New predictive models in humans, and new study designs are being sought to allow for confirmation of pharmacodynamic and potentially clinically meaningful effects in early development. This review focuses on human challenge models with lipopolysaccharide endotoxin, ozone, and rhinovirus, in the early clinical development phases of novel therapeutic agents for the treatment and reduction of exacerbations in COPD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Argentina | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 15% |
Student > Master | 6 | 15% |
Student > Bachelor | 6 | 15% |
Student > Ph. D. Student | 5 | 13% |
Student > Postgraduate | 3 | 8% |
Other | 7 | 18% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
Agricultural and Biological Sciences | 4 | 10% |
Immunology and Microbiology | 3 | 8% |
Chemistry | 2 | 5% |
Other | 6 | 15% |
Unknown | 8 | 20% |