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Potential role of histamine releasing factor (HRF) as a therapeutic target for treating asthma and allergy

Overview of attention for article published in Journal of Asthma and Allergy, September 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

twitter
3 tweeters
patent
1 patent

Citations

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21 Dimensions

Readers on

mendeley
31 Mendeley
Title
Potential role of histamine releasing factor (HRF) as a therapeutic target for treating asthma and allergy
Published in
Journal of Asthma and Allergy, September 2012
DOI 10.2147/jaa.s28868
Pubmed ID
Authors

Susan MacDonald

Abstract

Histamine releasing factor (HRF), also known as translationally controlled tumor protein (TCTP), is a highly conserved, ubiquitous protein that has both intracellular and extracellular functions. Here, we will highlight the history of the molecule, its clinical implications with a focus on its extracellular functioning, and its potential role as a therapeutic target in asthma and allergy. The cells and cytokines produced when stimulated or primed by HRF/TCTP are detailed as well as the downstream signaling pathway that HRF/TCTP elicits. While it was originally thought that HRF/TCTP interacted with IgE, the finding that cells not binding IgE also respond to HRF/TCTP called this interaction into question. HRF/TCTP, or at least its mouse counterpart, appears to interact with some, but not all IgE and IgG molecules. HRF/TCTP has been shown to activate multiple human cells including basophils, eosinophils, T cells, and B cells. Since many of the cells activated by HRF/TCTP participate in the allergic response, extracellular functions of HRF/TCTP may exacerbate the allergic, inflammatory cascade. Particularly exciting is that small molecule agonists of Src homology 2-containing inositol phosphatase-1 have been shown to modulate the phosphoinositide 3-kinase/AKT pathway and may control inflammatory disorders. This review discusses this possibility in light of HRF/TCTP.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Serbia 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 29%
Student > Ph. D. Student 7 23%
Student > Bachelor 3 10%
Student > Master 3 10%
Student > Doctoral Student 2 6%
Other 4 13%
Unknown 3 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 29%
Agricultural and Biological Sciences 8 26%
Immunology and Microbiology 5 16%
Medicine and Dentistry 4 13%
Chemistry 1 3%
Other 0 0%
Unknown 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2019.
All research outputs
#5,874,028
of 22,232,844 outputs
Outputs from Journal of Asthma and Allergy
#158
of 418 outputs
Outputs of similar age
#39,198
of 153,006 outputs
Outputs of similar age from Journal of Asthma and Allergy
#2
of 3 outputs
Altmetric has tracked 22,232,844 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 418 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 153,006 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.