Title |
Pegylated liposomal doxorubicin in malignant pleural mesothelioma: a possible guardian for long-term survival
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Published in |
OncoTargets and therapy, September 2012
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DOI | 10.2147/ott.s36915 |
Pubmed ID | |
Authors |
Paul Zarogoulidis, Maria Mavroudi, Konstantinos Porpodis, Kalliopi Domvri, Antonios Sakkas, Nikolaos Machairiotis, Aikaterini Stylianaki, Anastasios Tsiotsios, Nikolaos Courcoutsakis, Konstantinos Zarogoulidis |
Abstract |
Malignant pleural mesothelioma is a rare and aggressive malignancy of the pleura correlated with exposure to asbestos, with a medium survival of 11-12 months after diagnosis. A case of a 67-year-old male who had previously worked in the asbestos industry and is a current smoker is reported. The computed tomography evaluation revealed a right pleural mass with pleural thickening, and the pleural biopsy confirmed a diagnosis of malignant pleural mesothelioma. He was treated with chemotherapy consisting of etoposide, paclitaxel, and pegylated liposomal doxorubicin hydrochloride. After completion of chemotherapy, radiologic evaluation confirmed a reduction of pleural thickening and improvement in his symptoms. A complete presentation of each drug formulation and characteristics are also included in this paper. The patient's follow-up is continuing, and computed tomography reveals stable disease 9 years after initial examination. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 33% |
Student > Bachelor | 1 | 11% |
Student > Postgraduate | 1 | 11% |
Unknown | 4 | 44% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 33% |
Immunology and Microbiology | 1 | 11% |
Agricultural and Biological Sciences | 1 | 11% |
Unknown | 4 | 44% |