Title |
Co-nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: in vitro evaluation of cytotoxicity and magnetohyperthermia efficacy
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Published in |
International Journal of Nanomedicine, October 2012
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DOI | 10.2147/ijn.s35279 |
Pubmed ID | |
Authors |
Luciana LC Estevanato, Jaqueline R Da Silva, André M Falqueiro, Ewa Mosiniewicz-Szablewska, Piotr Suchocki, Antônio C Tedesco, Paulo C Morais, Zulmira GM Lacava |
Abstract |
Antitumor activities have been described in selol, a hydrophobic mixture of molecules containing selenium in their structure, and also in maghemite magnetic nanoparticles (MNPs). Both selol and MNPs were co-encapsulated within poly(lactic-co-glycolic acid) (PLGA) nanocapsules for therapeutic purposes. The PLGA-nanocapsules loaded with MNPs and selol were labeled MSE-NC and characterized by transmission and scanning electron microscopy, electrophoretic mobility, photon correlation spectroscopy, presenting a monodisperse profile, and positive charge. The antitumor effect of MSE-NC was evaluated using normal (MCF-10A) and neoplastic (4T1 and MCF-7) breast cell lines. Nanocapsules containing only MNPs or selol were used as control. MTT assay showed that the cytotoxicity induced by MSE-NC was dose and time dependent. Normal cells were less affected than tumor cells. Cell death occurred mainly by apoptosis. Further exposure of MSE-NC treated neoplastic breast cells to an alternating magnetic field increased the antitumor effect of MSE-NC. It was concluded that selol-loaded magnetic PLGA-nanocapsules (MSE-NC) represent an effective magnetic material platform to promote magnetohyperthermia and thus a potential system for antitumor therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Chile | 1 | 2% |
Netherlands | 1 | 2% |
India | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 55 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 24% |
Student > Master | 8 | 14% |
Student > Bachelor | 8 | 14% |
Student > Doctoral Student | 4 | 7% |
Researcher | 4 | 7% |
Other | 13 | 22% |
Unknown | 8 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 20% |
Materials Science | 7 | 12% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Medicine and Dentistry | 5 | 8% |
Physics and Astronomy | 3 | 5% |
Other | 13 | 22% |
Unknown | 12 | 20% |