| Title |
Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results
|
|---|---|
| Published in |
OncoTargets and therapy, July 2016
|
| DOI | 10.2147/ott.s105239 |
| Pubmed ID | |
| Authors |
Phuc Van Pham, Hanh Thi Le, Binh Thanh Vu, Viet Quoc Pham, Phong Minh Le, Nhan Lu-Chinh Phan, Ngu Van Trinh, Huyen Thi-Lam Nguyen, Sinh Truong Nguyen, Toan Linh Nguyen, Ngoc Kim Phan |
| Abstract |
Breast cancer (BC) is one of the leading cancers in women. Recent progress has enabled BC to be cured with high efficiency. However, late detection or metastatic disease often renders the disease untreatable. Additionally, relapse is the main cause of death in BC patients. Breast cancer stem cells (BCSCs) are considered to cause the development of BC and are thought to be responsible for metastasis and relapse. This study aimed to target BCSCs using dendritic cells (DCs) to treat tumor-bearing humanized mice models. NOD/SCID mice were used to produce the humanized mice by transplantation of human hematopoietic stem cells. Human BCSCs were injected into the mammary fat pad to produce BC humanized mice. Both hematopoietic stem cells and DCs were isolated from the human umbilical cord blood, and immature DCs were produced from cultured mononuclear cells. DCs were matured by BCSC-derived antigen incubation for 48 hours. Mature DCs were vaccinated to BC humanized mice with a dose of 10(6) cells/mice, and the survival percentage was monitored in both treated and untreated groups. The results showed that DC vaccination could target BCSCs and reduce the tumor size and prolong survival. These results suggested that targeting BCSCs with DCs is a promising therapy for BC. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 31% |
| Student > Ph. D. Student | 5 | 14% |
| Researcher | 3 | 9% |
| Student > Doctoral Student | 2 | 6% |
| Student > Master | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 9 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 17% |
| Medicine and Dentistry | 5 | 14% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Immunology and Microbiology | 3 | 9% |
| Engineering | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 11 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2022.
All research outputs
#14,915,133
of 25,374,647 outputs
Outputs from OncoTargets and therapy
#744
of 3,016 outputs
Outputs of similar age
#196,838
of 367,269 outputs
Outputs of similar age from OncoTargets and therapy
#25
of 110 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,016 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 74% of its peers.
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We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.