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The importance of norepinephrine in depression

Overview of attention for article published in Neuropsychiatric Disease and Treatment, May 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#17 of 2,992)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
20 news outlets
twitter
15 tweeters
facebook
2 Facebook pages
wikipedia
1 Wikipedia page
googleplus
2 Google+ users
video
9 video uploaders

Citations

dimensions_citation
225 Dimensions

Readers on

mendeley
619 Mendeley
Title
The importance of norepinephrine in depression
Published in
Neuropsychiatric Disease and Treatment, May 2011
DOI 10.2147/ndt.s19619
Pubmed ID
Authors

Mike Briley, Moret Chantal

Abstract

Depression is one of the most common psychological diseases with significant potential morbidity and mortality. Although the underlying pathophysiology of depression has not been clearly defined, preclinical and clinical evidence suggest disturbances in serotonin (5-HT), norepinephrine (NE), and dopamine (DA) neurotransmission in the central nervous system. Virtually all currently available antidepressants act on one or more of the following mechanisms: inhibition of reuptake of 5-HT or NE (and DA), antagonism of inhibitory presynaptic 5-HT or NE receptors, or inhibition of monoamine oxidase. All of these mechanisms result in an enhanced neurotransmission of 5-HT and/or NE. Evidence for the involvement of NE in depression is abundant, and recent studies on neuronal pathways and symptoms highlight the specific role of NE in this disorder. NE plays a determinant role in executive functioning regulating cognition, motivation, and intellect, which are fundamental in social relationships. Social dysfunction is possibly one of the most important factors affecting the quality of life in depressed patients.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 619 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 <1%
Mexico 1 <1%
United States 1 <1%
Brazil 1 <1%
Unknown 613 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 180 29%
Student > Master 79 13%
Student > Ph. D. Student 69 11%
Researcher 49 8%
Other 27 4%
Other 73 12%
Unknown 142 23%
Readers by discipline Count As %
Medicine and Dentistry 85 14%
Biochemistry, Genetics and Molecular Biology 70 11%
Psychology 69 11%
Neuroscience 69 11%
Agricultural and Biological Sciences 48 8%
Other 116 19%
Unknown 162 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 176. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2022.
All research outputs
#191,056
of 22,953,506 outputs
Outputs from Neuropsychiatric Disease and Treatment
#17
of 2,992 outputs
Outputs of similar age
#594
of 110,564 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#1
of 18 outputs
Altmetric has tracked 22,953,506 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,992 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 110,564 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.