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Dove Medical Press

The importance of norepinephrine in depression

Overview of attention for article published in Neuropsychiatric Disease and Treatment, May 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#27 of 3,132)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
21 news outlets
twitter
16 X users
facebook
2 Facebook pages
wikipedia
1 Wikipedia page
googleplus
2 Google+ users
video
10 YouTube creators

Citations

dimensions_citation
270 Dimensions

Readers on

mendeley
713 Mendeley
Title
The importance of norepinephrine in depression
Published in
Neuropsychiatric Disease and Treatment, May 2011
DOI 10.2147/ndt.s19619
Pubmed ID
Authors

Chantal Moret, Mike Briley

Abstract

Depression is one of the most common psychological diseases with significant potential morbidity and mortality. Although the underlying pathophysiology of depression has not been clearly defined, preclinical and clinical evidence suggest disturbances in serotonin (5-HT), norepinephrine (NE), and dopamine (DA) neurotransmission in the central nervous system. Virtually all currently available antidepressants act on one or more of the following mechanisms: inhibition of reuptake of 5-HT or NE (and DA), antagonism of inhibitory presynaptic 5-HT or NE receptors, or inhibition of monoamine oxidase. All of these mechanisms result in an enhanced neurotransmission of 5-HT and/or NE. Evidence for the involvement of NE in depression is abundant, and recent studies on neuronal pathways and symptoms highlight the specific role of NE in this disorder. NE plays a determinant role in executive functioning regulating cognition, motivation, and intellect, which are fundamental in social relationships. Social dysfunction is possibly one of the most important factors affecting the quality of life in depressed patients.

X Demographics

X Demographics

The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 713 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 <1%
Mexico 1 <1%
United States 1 <1%
Unknown 708 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 190 27%
Student > Master 88 12%
Student > Ph. D. Student 77 11%
Researcher 48 7%
Student > Doctoral Student 29 4%
Other 94 13%
Unknown 187 26%
Readers by discipline Count As %
Medicine and Dentistry 93 13%
Neuroscience 76 11%
Biochemistry, Genetics and Molecular Biology 74 10%
Psychology 70 10%
Agricultural and Biological Sciences 51 7%
Other 140 20%
Unknown 209 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 180. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2024.
All research outputs
#223,142
of 25,374,917 outputs
Outputs from Neuropsychiatric Disease and Treatment
#27
of 3,132 outputs
Outputs of similar age
#700
of 121,545 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#1
of 18 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,132 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,545 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.